Macromolecular docking restrained by a small angle X-ray scattering profile

Small Angle X-ray Scattering from Macromolecular Solutions and Nanoparticles

Small-angle X-ray scattering (SAXS) experiences a renaissance in the studies of macromolecular solutions allowing one to study the structure of native particles and to rapidly analyze structural changes in response to variations in external conditions [1]. Novel data analysis methods significantly enhanced resolution and reliability of structural models provided by the technique. Emerging autom...

Accounting for observed small angle X-ray scattering profile in the protein-protein docking server cluspro

The protein-protein docking server ClusPro is used by thousands of laboratories, and models built by the server have been reported in over 300 publications. Although the structures generated by the docking include near-native ones for many proteins, selecting the best model is difficult due to the uncertainty in scoring. Small angle X-ray scattering (SAXS) is an experimental technique for obtai...

Application of small angle X-ray scattering (SAXS) for differentiation between normal and cancerous breast tissues

ABSTRACT Background: Coherent scattering leads to diffraction effects and especially constructive interferences. Theseinterferences carry some information about the molecular structure of the tissue. As breast cancer isthe most widespread cancer in women, this project evaluated the application of small angleX-ray scattering (SAXS) for differentiation between normal and cancerous breast tissues....

Investigating Macromolecular Complexes in Solution by Small Angle X-Ray Scattering

Ultra-small-angle X-ray Scattering